Berberine inhibited hepatic necroinflammation, IL-1β, and NLRP3 inflammasome in non-alcoholic steatohepatitis (NASH) induced by methionine and choline - deficient diet in mouse, which based on interference with activation of P2x7, a purinergic receptor involved in inflammasome activation (Vivoli et al., 2016). This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatohepatitis.