The polyphenolic compound, curcumin, was reported to decrease serum ALT, TNF-α, IFN-γ, and hepatic necrosis and apoptosis in propionibacterium acnes-induced liver injury (Gu et al., 2015) and Con A-induced hepatitis (Wang et al., 2012), which related to its inhibition on HMGB1 cytoplasmic translocation and expression by down-regulation of acetylation of lysine. This evidence concerns the gene TNF and hepatitis A virus infection.