Detailed statistical analysis showed that, ThioS-positive amyloid plaque areas were markedly reduced in the brains of NDC-treated APP/PS1 mice compared with that in the brains of vehicle-treated APP/PS1 mice (Figures 3B,C), and 6E10-positive amyloid plaque areas were also significantly reduced (Supplementary Figure S1), indicating that NDC treatment alleviates the deposition of amyloid plaques. Here, APP is linked to amyloidosis.