MAPT and Alzheimer disease: For instance, curcumin and its derivatives which are suggested to have therapeutic potential for AD by inhibiting Aβ production and tau phosphorylation (Yang et al., 2005; Necula et al., 2007; Ma et al., 2009), stimulating embryonic neural stem cell proliferation via the MAP kinase pathways, and enhancing adult hippocampal neurogenesis (Kim et al., 2008).