For example, controlled cortical impact leads to an upregulation of APP and BACE1 expression in wild-type rats (Blasko et al., 2004; Acosta et al., 2017) and accelerates Aß deposition in transgenic-AD mice (Tajiri et al., 2013; Washington et al., 2014; Shishido et al., 2016). Here, APP is linked to Alzheimer disease.