APOE and Alzheimer disease: Indeed, a diabetic phenotype does increase the expression of Aß in AD-Tg mice (Ho et al., 2004), is sufficient to do the same in wild-type rabbits (Bitel et al., 2012), and is associated with greater plaque pathology in the subset of diabetic AD patients with an APOE ε4 genotype (Malek-Ahmadi et al., 2013).