SLC1A2 and Alzheimer disease: Inhibition of CN/NFAT pathway in hippocampal astrocytes through the selective viral-mediated expression of VIVIT in astrocytes improved cognitive and synaptic function, reduced glial activation, lowered Aβ levels, increased GLT-1 expression, and reduced glutamate-mediated neuronal excitotoxicity in plaque-bearing AD mice (Furman et al., 2012; Sompol et al., 2017).