However, neuropathological studies in AD brains addressing the cell type responsible for this increase have revealed that NFκB immunoreactivity is increased in the cytoplasm and nucleus of neurons, especially those surrounding amyloid plaques or bearing a NFT (Terai et al., 1996; Kaltschmidt et al., 1997; Ferrer et al., 1998). This evidence concerns the gene NFKB1 and Alzheimer disease.