APOE and tauopathy: Remarkably, although large clinico-pathological studies have established that the APOEε4 allele does not increase either the burden or the Braak stages of NFTs independently of amyloid plaques (Serrano-Pozo et al., 2015; Farfel et al., 2016), apoE4 has recently been shown to promote tau pathology and neurodegeneration in a mouse model of tauopathy (Shi et al., 2017).