MAPT and tauopathy: Indeed, E4FAD and P301S/E4 mice (corresponding to the 5xFAD mouse model of brain β-amiloidosis and the P301S tau transgenic mouse of tauopathy under a human APOEε4 KI background, respectively) have a hyperactivated microglia and increased levels of proinflammatory cytokines as compared to the APOEε3 and APOEε2 KI double transgenic mice (Rodriguez et al., 2014; Shi et al., 2017).