A recent postmortem quantitative neuropathological study in AD and other tauopathies has described that YKL-40 is only expressed by a subset of GFAP-immunoreactive astrocytes and that there is a positive correlation between YKL-40 and tau immunoreactivities, in agreement with the correlations found in CSF (Querol-Vilaseca et al., 2017). This evidence concerns the gene MAPT and Alzheimer disease.