IL33 and Alzheimer disease: The neuroprotective effects of IL-33, an important inflammatory regulator, have been demonstrated in previous studies involving CNS diseases and injury, such as AD (Xiong et al., 2014), MS (Jafarzadeh et al., 2016), chronic pain (Longhi-Balbinot et al., 2016), ICH (Gao et al., 2017); however, the roles of IL-33 in TBI and the underlying mechanisms needed to address.