In MetS, innate immune functions are co-modified with inflammatory elements: the MetS-upregulated lincRNA Cox2 modulates the expression of inflammatory-associated proteins, such as chemokines and interferon-stimulated genes (Carpenter et al., 2013), and the p50-associated lncRNA PACER leads the assembly of NF-kB transcription complexes, which are major promoters of inflammatory cellular processes (Krawczyk and Emerson, 2014). The gene discussed is NFKB1; the disease is metabolic syndrome.