The Lethe lncRNA is involvedplay a role both in sepsis and in MetS in NF-kB regulation, and is co-induced with interleukin (IL)-1β and tumor necrosis factor (TNF)α, and downregulated by high-glucose environment, where it exacerbates the inflammatory cellular profile (Zgheib et al., 2017). The gene discussed is TNF; the disease is Sepsis.