The experimental results presented in Fig. 9a–g revealed that the activity of CYP7A1, LXRA, and PPARα in the liver of high-fat diet rats was upregulated following the administration of COSTC compared with in the HF group (p ≤ 0.05), although COSTC-L did not show significance. The gene discussed is NR1H3; the disease is hydrops fetalis.