CD38 and acute myeloid leukemia: When tested at lower concentration, we determined that all three corticosteroids are effective in the low nanomolar range against 8227 AML CD34+ CD38− cells (LC50 budesonide = 1.41 nM, mometasone = 0.57 nM, halcinonide = 1.20 nM) (Fig. 6a).