As shown in Fig. 4a, b, the density of CD8+ T cells was significantly higher in tumours with Mφ-PD-L1+ compared with that in Mφ-PD-L1− tumours (p < 0.0001); whereas there was no correlation between TC-PD-L1 expression and CD8+ T-cell infiltration. Here, CD274 is linked to neoplasm.