Differential gene expression analysis using a microarray revealed that several genes were commonly upregulated among TC-related genes, such as CDK20. A recent study showed that combined CDK20 inhibition with immune checkpoint blockade might provide more efficient therapeutic effects for patients with HCC.54 However, the relationship and underlying mechanism of the association of these genes with PD-L1 expression in HCC is unclear and requires further investigation. This evidence concerns the gene CD274 and hepatocellular carcinoma.