Several groups have attempted to assess the relationship between PD-L1 expression and patients’ outcome in HCC; however, these studies mostly examined the overall expression of PD-L1, or simply classified PD-L1 expression on TCs or immune cells by IHC staining.48,49 In the present study, CD68 and PD-L1 double staining was applied to determine the positive cell types for PD-L1. Here, CD274 is linked to hepatocellular carcinoma.