We addressed this question in a large Scandinavian case-control cohort (n = 8172 cases and 13,263 controls, cohort 4, Supplementary Data 1) by testing association of the SNPs (45/50 with genotype data) with MS after adjusting for DRB1*15:01 (and associated terms) and all other established risk variants in the HLA locus5 (Fig. 6a, Supplementary Data 7). This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.