GCG and type 2 diabetes mellitus: As T2D is characterized by a sustained increase in blood glucose levels after each meal, we wanted to capture the natural dynamics of caffeine uptake after each major meal to achieve a novel therapeutic approach to the acute phase of T2D by using designer cells equipped with C-STAR to deliver synthetic human glucagon-like peptide 1 (shGLP-1) in response to dietary intake of coffee or other caffeine-containing beverages.