LYN and colorectal cancer: These lipid modifications are important for appropriate functioning of Src-family kinases: palmitoylation is required for accumulation of Lyn to lipid rafts and the involvement of Lyn in lipopolysaccharide-induced signaling in RAW264 macrophage-like cells [71]; palmitoylation of c-Yes mediates oncogenic signaling in HT29 colorectal cancer cells [72]; the lack of lipid modifications in c-Src and Lyn causes chromosome missegregation in mitotic HeLa S3 cells [73].