BCL6 and diffuse large B-cell lymphoma: However, BI-3802/BCL6-BCL6 trimer complex formation results in subsequent ubiquitinylation and degradation of the BCL6 repressor, leading to an anti-proliferative activity in diffuse large B cell lymphoma and induced expression of BCL6-repressed genes such as ATM, DUSP5 and IRF4, a transcription factor associated with B cell maturation [103].