The hydronaphthoquinones S01, S05 and S47 activities were not compared to Cpd16 activity but were evaluated using cellular and in vivo experiments, showing that both S01 and S05 induce nuclear translocation of Nrf-2 and quickly activate the expression of target genes such as the heme oxygenase-1 and the NADPH-quinone oxidoreductase 1, reduces LPS-induced pro-inflammatory cytokines such as TNF-α, IL1β and IL-6 and LPS-induced cell death in mice, suggesting that they could be used in cancer chemoprevention [134]. The gene discussed is NFE2L2; the disease is cancer.