MEN1 and leukemia: MIV-6 differs from ML227 by an amine group that substitute to the hydroxyl group of ML227 and is more stable but with similar range of IC50 for menin (185 nM) whereas M-525 is much more efficient on menin interaction with IC50 of 3.3 nM and is 30-fold more potent in cellular activities with a hiogh specificity on mixed lineage leukemia cell models such as MV4;11 [57].