Interestingly, H3N2 influenza virus subtype-infection induces comparable TNF-α, IL-12, IP-10, and IL-6 levels in both M1-like and M2-like monocytes and macrophages, and both macrophage types could be readily infected with this virus; an observation in marked contrast with the clearly distinct cytokine profiles of M1-like and M2-like macrophages exposed to bacterial products [63]. The gene discussed is TNF; the disease is infection.