However, compared with the non-CHB group, patients with RA with CHB experienced smaller improvements from baseline in most disease activity indicators, mainly at month 12, including PtGA, PrGA, Pain VAS, HAQ-DI, DAS28-CRP, SDAI, and CDAI, especially RAPID3 at almost each point except month 3 (all p <  0.05) (Fig. 2). Here, CRP is linked to rheumatoid arthritis.