TNF and rheumatoid arthritis: This is consistent with previous RCTs of sarilumab administered in combination with csDMARDs in MTX-IR and tumor necrosis factor inhibitor (TNFi)-IR RA populations [11, 13] and of adalimumab administered in combination with MTX in patients with early RA or as a monotherapy in patients with active RA who are intolerant of or inappropriate for continued MTX treatment [37, 38].