Multivariate Cox regression analysis indicated that CHIP expression and tumor differentiation had statistical significances, with hazard ratio of 7.163 for CHIP (95% CI 2.188–23.453, P = 0.001) and 3.030 for tumor differentiation (95% CI 1.485–6.180, P = 0.002), indicating the CHIP expression and tumor differentiation were independent prognostic factors in the development of CRC. Here, STUB1 is linked to neoplasm.