Real‐time PCR results showed that HK‐2 was significantly increased in RV but not in LV of DCM pigs compared to controls (Figure 2B), GYSI was unaltered (Figure 2C), and PYGM was significantly down‐regulated in both ventricles (Figure 2D) of our in vivo model, suggesting an inactivation of glycogen degradation pathway in the heart of DCM pigs. Here, PYGM is linked to familial dilated cardiomyopathy.