HMOX1 and Sepsis: Similar phenomena were also observed in previous studies of other organ I/R injury or other inflammatory diseases.35, 36, 37, 38 Molecular hydrogen could attenuate intestinal injury in wild‐type but not NRF2‐knockout mice with severe sepsis by regulating HO‐1 expression.37 Therefore, hydrogen might activate the Nrf2/ARE pathway to restore the homoeostasis of cutaneous oxidation‐reduction system against I/R injury.