CD103−CD11b+ cDC, in contrast, are important for the induction of Th2 responses in the large intestine.47, 48 Mice deficient in IRF4 or Notch2 have reduced numbers of CD103−CD11b+ cDC and fail to mount Th2 responses to helminth infections including T. muris. Here, IRF4 is linked to helminthiasis.