HLA-C and parasitic infectious disease: The proteasome is known to play a key function in MHC protein processing and antigen presentation [23], the genes in this module could therefore be of special interest regarding the development of adaptive immune responses against P. falciparum. The study by Dunachie et al. [19] further reported the antigen processing and presentation pathway and phosphotidylinositol signaling system to be key modules invoked by antigen stimulation after vaccination and the latter to be correlated with time to parasitemia in subsequent challenge by mosquito bite [19].