These results indicate that expression of CXCR7 improve prognosis in DLBCL only when co-expressed with CXCR4, and this happens by reverting the poor prognosis associated to CXCR4+ tumors towards a favorable prognosis similar to that observed in CXCR4- tumors. Here, CXCR4 is linked to diffuse large B-cell lymphoma.