Dolinay et al. focused on inflammasome-regulated cytokines during ARDS and found an up-regulation of the inflammasome component ASC as well as IL1B gene, the latter together with IL-18 also found in the plasma of enrolled patients.[15] In our analysis, we can confirm the robust up-regulation of several genes belonging to the IL1/18 axis, e.g. the decoy receptor IL1R2 together with IL18R. Here, IL18R1 is linked to acute respiratory distress syndrome.