HP and Sepsis: Binary logistic regression for sepsis (both clusters) vs. healthy controls extracted a diagnostic panel of five genes (CD177, HLA-DRB1, HP, IL7R, AZU1) and subsequent ROC analysis of combined probability revealed an AUC of 0·977 (CI: 0·967–0·987; derivation set) respectively 0.985 (CI: 0.974–0.996; validation set) (S7A Fig).