LRP1 and osteoarthritis: In summary, the current study makes a functional link between IFT and protease activity in chondrocytes via a regulatory axis that is highly relevant to osteoarthritis; however, this link between IFT and LRP-1–mediated endocytosis may be relevant in other pathophysiologic scenarios in which LRP-1 plays putative roles, such as in atherosclerotic and neuronal plaques (61).