Itaconate accumulation is catalyzed by the enzyme encoded by Irg1 (20); accordingly, we found that Irg1 mRNA expression was significantly upregulated in pResMφ from mice bearing B16, 3LL, or MC38 tumors (Figure 3C) as well as in mice bearing ID8, IG10, or IF5 ovarian carcinomas (Figure 3D). The gene discussed is ACOD1; the disease is ovarian carcinoma.