TNXB and Ehlers-Danlos syndrome, hypermobility type: 2017) and GI manifestations are particularly common in these patients. For instance, case studies in TNX‐deficient patients report constipation, rectal prolapse, abdominal pain, diverticulosis and hiatal hernia (Schalkwijk et al. 2001; Lindor & Bristow, 2005). However, the cellular mechanisms mediating GI symptoms are yet to be described. TNX‐deficient mice show musculoskeletal and cutaneous features of hEDS (Mao et al. 2002) while other aspects of physiology remain uninvestigated.