Except for one case study of polycythemia vera (Tiziana Storlazzi et al., 2014), no SETD1B mutations in human hematologic malignancies such as myeloproliferative neoplasm (MPN), myelodysplastic syndrome (MDS), and AML have been reported so far. The gene discussed is SETD1B; the disease is myeloproliferative disorder.