However, major phenotypic hallmarks of the Setd1b vKO mouse (e.g. multilineage cytopenia and dysplasia) are reminiscent of human MDS according to WHO classification and adapted diagnostic criteria in mice (Kogan et al., 2002; Vardiman et al., 2009; Zhou et al., 2015). This evidence concerns the gene SETD1B and myelodysplastic syndrome.