Hematologic malignancies, including myeloproliferative neoplasm (MPN) and myelodysplastic syndrome (MDS), are typically characterized by disturbed HSPC homeostasis and often develop into acute myeloid leukemia (AML) (Corey et al., 2007; Kitamura et al., 2014). Here, PSMA7 is linked to myelodysplastic syndrome.