In humans, mutations in the SETD1B gene have been detected in different kinds of malignancies including oesophageal squamous cell carcinoma (Song et al., 2014), gastric and colorectal cancer (Choi et al., 2014), endometrial carcinoma (GarciaGarcía-Sanz et al., 2017) and polycythemia vera (Tiziana Storlazzi et al., 2014). This evidence concerns the gene SETD1B and acquired polycythemia vera.