Similarly, there is an essential requirement for Sec24B in the trafficking of the planar cell polarity protein Vangl2; mutations in Sec24B in mice cause craniorachischisis (Merte et al. 2010; Wansleeben et al. 2010) and related mutations in humans result in neural tube defects (Yang et al. 2013). This evidence concerns the gene SEC24B and craniorachischisis.