BSN and epilepsy: Considering the role of Bassoon in regulated neurotransmitter release (Altrock et al. 2003; Gundelfinger et al. 2016) and the importance of the GABAergic system in epilepsy (Treiman 2001), we suggest that absence of Bassoon from inhibitory synapses during network development and/or epileptic seizure activity may contribute to impaired long-term plasticity in constitutive Bsn mutants.