CCR4 and synovial sarcoma: A multiplatform genomic analysis of patients with SS detected (1) activating CCR4 and caspase recruitment domain-containing protein 11 (CARD11) mutations in nearly one-third of patients; (2) deletion of zinc finger E-box binding homeobox 1 (ZEB1), encoding a transcriptional repressor essential for T-cell differentiation, in over one-half of patients; and (3) overexpression of interleukin 32 (IL-32) and interleukin-2 receptor subunit gamma in nearly all patients (21).