The role of Dectin-1 is still controversial, since no significant differences were observed in the clinical course and cytokine production between Dectin-1-deficient and control mice in a cryptococcosis model (248), but another study found that C. neoformans spores are phagocytosed by murine AMs via Dectin-1 (18). The gene discussed is CLEC7A; the disease is cryptococcosis.