Investigations of miRNAs have found upregulation of miR-29b (36), miR-141, miR-200a (22), miR-155 (37), miR-223 (38), miR-326 (39), let-7e (40), and miR-448 (41), and significant downregulation of miR-15a/16-1 (42) and miR-15b (43) in CD4+ T cells of MS patients and EAE models. Here, CD4 is linked to myeloid sarcoma.