miR-155 and miR-223, which are confirmed to be upregulated in MS and EAE models, simultaneously promote Th17 and Th1 cell differentiation in EAE mice (21) with the requirement of optimal dendritic cell production of cytokines IL-1β, IL-6 and IL-23 (37, 38). This evidence concerns the gene IL1B and myeloid sarcoma.