In fact, the level of mRNA expression of genes such as IL-18, IL-1β, IL-1 receptor antagonist, NACHT, LRR, and PYD domain-containing protein 3 (NALP3), and caspase1 is upregulated in PBMCs from RR-MS patients in comparison with healthy donors (47). This evidence concerns the gene IL1B and myeloid sarcoma.