The beneficial AMPK/mTOR/STAT3-dependent effect of metformin on Th17-mediated inflammation was further confirmed in collagen-induced arthritis (CIA) (37–39), dextran sulfate sodium-induced colitis (reminiscent of human inflammatory bowel disease, IBD) (40), Roquinsan/san model of SLE (41), and acute graft-versus-host disease (42). Here, STAT3 is linked to inflammatory bowel disease.