However, in 5XFAD mice carrying five mutations associated with early onset familial AD, the depletion of Foxp3+ Tregs was accompanied with increased Aβ clearance and reversal of cognitive decline and in a model for neuronal injury in BALB/c/OLA mice, the transfer of CD4+CD25+ Tregs worsened the outcome, indicating a deleterious effect of Tregs in these models (49, 50). Here, CD4 is linked to Mental deterioration.