Our findings suggest that in AD but not in controls the number of CD4+CD127lowCD25+ Treg cells was rather related to the level of Tau and pTau181, which predict the rate of cognitive decline in the different stages of AD and correlated with neurofibrillary tangle pathology in the neocortex in AD brains (35, 36, 46, 47). This evidence concerns the gene CD4 and Neurofibrillary tangles.