CD4 and dementia: However, Saresella et al. reported an increase of CD4+Foxp3+ Tregs in Alzheimer’s dementia especially in MCI diagnosed by NINCDS ADRA criteria, Le Page et al. reported an increase of CD4+Foxp3+CD25high cells in amnestic MCI but not in mild Alzheimer’s dementia, and Larbi et al. reported an overall decreased frequency of CD4+CD25high T cells in subjects with mild AD dementia when compared with age-matched controls (17, 44, 45).