Collectively, the percentage of CD4+CD127lowCD25+ Tregs in the AD group positively related to the level of neurodegeneration in means of increased levels of Tau/pTau181 and amyloidopathy in means of decrease of Aβ42/Aβ40 ratio, while in the nonAD group an inverse relation was observed. The gene discussed is MAPT; the disease is Alzheimer disease.