Further they showed that like PVT1, miR-1207-5p also increased the expression of TGF-β1, PAI-1, and FN1 independently of PVT1. This indicates that glucose and TGFβ1 regulates miR-1207-5p expression but in an independent manner of its host gene PVT1. Taken together, these results show that miR-1207-5p and its host gene play an important role in the pathogenesis of DN (38). The gene discussed is PVT1; the disease is liver dysplastic nodule.