Knockdown of Gm4419 inhibited the expression of pro-inflammatory cytokines, biomarkers of renal fibrosis, and reduced cell proliferation in MCs, suggesting that lincRNA-Gm4419 promoted MC inflammation, fibrosis and proliferation hyperglycemic condition through NF-κB/NLRP3 inflammasome pathway (34). Here, NFKB1 is linked to renal fibrosis.