SSTR5 and Cowden disease: Pasireotide, a multi-somatostatin receptor ligand that is able to bind four of the five known SSTR subtypes (SSTRs1–3 and SSTR5) with a 40-fold greater binding affinity for SSTR5 with respect to octreotide (59, 60), was the first agent to be approved for the treatment of adult CD patients.