INS and Hyperglycemia: When lifestyle changes and maximally tolerable dose of metformin fail to control hyperglycemia, other anti-hyperglycemic drugs are necessary to better control of glucose including oral antihyperglycemic drugs (sulfonylureas, thiazolidinedione, DPP4 inhibitors, alpha glucosidase inhibitors etc.)and injectable anti-hyperglycemic drugs (insulin, Glucagon-like peptide-1 receptor agonists etc.)(Koro et al., 2004; Doggrell, 2018).