SNAI1 and neoplasm: Furthermore, Teo et al. observed increased 14-3-3γ expression with tumor stage for breast, colorectal, gastric, and head and neck cancers, which corresponded to prolonged hypoxia-dependent increases in 14-3-3γ expression which they showed mediate inhibition of TSC2 and also activation of Snai1 to promote an epithelial-mesenchymal transition (EMT), thus highlighting a 14-3-3-mediated adaptation acquired by tumor cells to promote survival [125].