When we considered the specific cancer histology of TCLs, rather than analysing these en mass, we found in both the Achilles and DRIVE data sets the Rb/SKP2 synthetic lethality was detectable in TCLs derived from lung cancers (p = 0.026/SLP = 71% and p = 0.0008/SLP = 73% for DRIVE and Achilles, respectively; Fig. 7e, f). Here, RB1 is linked to lung cancer.