For example, the hyper-proliferative phenotype of Rb-depleted human retinoblastoma cells and mouse melanotrophs is dependent upon the SKP2 [48, 62] and the SKP2/CKS1 pocket inhibitor, SKPinC1, inhibits Rb/p53-defective mouse prostate tumour cell organoids [63]. This evidence concerns the gene TP53 and retinoblastoma.