In conclusion, inhibition of VAP-1/SSAO reduces atherosclerosis in cholesterol-fed New Zealand White rabbits, which may act through the suppression of several important mechanisms for atherosclerosis, including reducing oxidative stress, lowering plasma lipids, decreasing endothelial cell activation, reducing recruitment and activation of macrophages, and suppressing migration and proliferation of SMC. The gene discussed is AOC3; the disease is atherosclerosis.