Next we interrogated the KEGG pathway and found the top up-regulated categories showed strong correlation with Alzheimer’s, Huntington’s and Parkinson’s diseases (Fig. 5F) by enriching genes such as ATP5D, ATP5H, HSD17B10 and NDUFB11, NDUFA8, NDUFB7, NDUFS8. The gene discussed is HSD17B10; the disease is Parkinson disease.