Interestingly, the expression changes of genes such as Gfap, Csf1, Prnp, C4b and Trem2, identified with 2 m Tau hippocampi (Fig. 2; GSE107183) have been observed at symptomatic stages in the same rTg4510 tauopathy model in other studies52,53. This evidence concerns the gene PRNP and tauopathy.