NOS3 and central nervous system cancer: In addition, eNOS and glioma invasiveness signalling were more activated whereas LXR/RXR and PPARα/RXRα activation, GnRH (Gonadotropin Releasing Hormone) signalling, α-adrenergic, and cardiac hypertrophy signalling were significantly deactivated in aCDCs (Fig. 2c and Table 1).