Recently, Mac-2-binding protein glycosylation isomer (M2BPGi), also known as Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP), is widely investigated as a potential marker for liver fibrosis in patients with viral hepatitis10 particularly chronic hepatitis C (CHC)11, non-alcoholic fatty liver disease (NAFLD)12, primary biliary cholangitis (PBC)13, autoimmune hepatitis (AIH)14 and biliary atresia15. This evidence concerns the gene LGALS3 and Hepatic fibrosis.