In the present study, in vivo screening of some candidate ETS proteins revealed that ELF-1, ETV-4, ETV-3L, ETS-1 and ETS-2 can enhance the LAIR-1 basic promoter activity with different efficiency, and the CHIP results confirmed that ETS-2 can bind to the LAIR-1 promoter sequence in Jurkat (an immortalized human T lymphocytes) and COC1 (one ovarian cancer cell lines) cells. Here, ETV4 is linked to ovarian cancer.