RB1 and neoplasm: The chromatin adaptor rbbp4, a component of multiple chromatin remodelers controlling gene expression including NuRD, PRC2, histone acetyltransferase p300 and the cell cycle DREAM/MuvB complex, was upregulated in both rb1 tumor (7.8-fold, Padj<0.00001) and rb1/rb1 mutant (2.3-fold, Padj<0.00001) transcriptomes (Fig. 4B, asterisk; Tables S3 and S6).