Like rbbp4, hdac1, the catalytic component of NuRD, and mbd3a, a DNA binding subunit, were both significantly overexpressed in the rb1 tumor (hdac1 3.6-fold, Padj<0.00001; mbd3a 6.1-fold, Padj<0.00001). This evidence concerns the gene RBBP4 and neoplasm.