Indeed, reduced levels of MIAT in PC9 lung cancer cells were recently found to be associated with a decrease in Bcl-2 and an increase in Bax expression levels [28], providing further evidence that associates reduced MIAT levels with an enhanced responses to a diverse range of cell death stimuli and raising the possibility that increased MIAT levels might contribute to the development of drug resistance in metastatic disease. This evidence concerns the gene BAX and metastatic neoplasm.