The first model of kyphoscoliosis peptidase (KY) deficiency was the ky/ky mouse, which emerged spontaneously as a model of recessive, hereditary kyphoscoliosis in an inbred mouse strain over 40 years ago (Dickinson and Meikle, 1973; Mason and Palfrey, 1984). This evidence concerns the gene LAP3 and Kyphoscoliosis.