CD73 expression within the tumor microenvironment has been studied as a prognostic biomarker for clinical outcomes in several tumor types, including breast cancer, lung cancer, ovarian cancer, kidney cancer, gastric cancer, prostate cancer, urothelial cancer, uterine cancer, melanoma, and head and neck cancers (Table 1) [2, 54–64, 66]. Here, NT5E is linked to melanoma.